Brandon Zanette, Rowan Thomson
Thursday, November 15, 2012

Time:   3:30 - 5:00 pm – November 15, 2012

Location:   Conference room A&B, Room C2362, 2nd floor, Cancer Centre South, The Ottawa Hospital General Campus


1.       “Validation of the Bookend Method in Dynamic Contrast Enhanced MRI”

Brandon Zanette – Carleton University

Abstract:  Dynamic Contrast Enhanced (DCE) MRI is a method used to obtain quantitative, biologically relevant information in a tissue of interest. DCE-MRI involves the use of a contrast agent injection which is tracked in time via a rapid T1-weighted imaging sequence. The contrast agent will cause a signal increase, which is proportional to its concentration in the tissue. One important use of DCE-MRI is the diagnosis and grading of cancer. There is often a distinct difference in parameter values measured with DCE-MRI between tumours and healthy tissue. The technique currently used for DCE measurements is susceptible to experimental error caused by spatial variation of the flip angle. The goals of this project are to gain a better understanding of this effect and to develop techniques to mitigate these errors, thereby improving concentration estimation.


2.       “Monte Carlo simulations on the cellular scale”

Rowan Thomson – Carleton University

Abstract:  Monte Carlo simulations are widely applied in radiotherapy for computing dose in macroscopic volumes of interest; however, there is increasing interest in applications at microscopic length scales.  This presentation will describe some recent research related to Monte Carlo simulations on cellular length scales.  The first part of the presentation will focus on cellular dosimetry for kilovoltage radiation and several cancerous and normal soft tissues.  This research investigates how alternative macroscopic dose descriptors track absorbed dose to biologically relevant cellular targets.  In the second part I will discuss research aimed at understanding the limitations of widely-used `classical' Monte Carlo simulations of low energy electron transport, and new work towards developing modelling techniques consistent with quantum theory.